Dept. of Cell Biology Klumperman Lab


Dept. of Cell Biology Klumperman Lab
J.Klumperman@umcutrecht.nl
J. Klumperman
University Medical Center Utrecht
Heidelberglaan 100
3584 CX
Utrecht
J. Klumperman

P.J. Coffer

F. Reggiori

P. van der Sluijs

M. Maurice

A. Martens

Fluorescence Microscopy

Live-cell imaging

SLEM

CLEM

(immuno-) electron microscopy

(immuno-) electron tomography

Endosomal trafficking and lysosome biogenesis

Autophagy, immunology

Hematooncology program, regenerative medicine

Mechanisms of Wnt signaling in stem cells, development and cancer

Molecular mechanisms of membrane traffic regulating cell surface remodeling

Cell biology of the growth hormone receptor

Pathogenesis of the hematological tumors multiple myeloma and acute myelocytic leukemia

Elstak ED, Neeft M, Nehme NT, Voortman J, Cheung M, Goodarzifard M, Gerritsen HC, van Bergen En Henegouwen PM, Callebaut I, de Saint Basile G, van der Sluijs P (2011), The munc13-4-rab27 complex is specifically required for tethering secretory lysosomes at the plasma membrane, Blood, 118, 1570-8.

van Meel E, Boonen M, Zhao H, Oorschot V, Ross FP, Kornfeld S, Klumperman J (2011), Disruption of the man-6-p targeting pathway in mice impairs osteoclast secretory lysosome biogenesis, Traffic, 12, 912-24.

Nair U, Jotwani A, Geng J, Gammoh N, Richerson D, Yen W-L, Griffith J, Nag S, Wang K, Moss T, Baba M, McNew JA, Jiang X, Reggiori F*, Melia TJ, Klionsky DJ (2011), SNARE proteins are required for macroautophagy, Cell, 46, 290-302. *co-corresponding author

Mari M, Griffith J, Rieter E, Krishnappa L, Klionsky DJ, Reggiori F (2010), Key role of a novel Atg9-containing compartment in the early steps of autophagosome biogenesis, J Cell Biol, 190, 1005-1022.

Hoogenraad CC, Popa I, Futai K, Martinez-Sanchez E, Wulf PS, van Vlijmen T, Dortland BR, Oorschot V, Govers R, Monti M, Heck AJ, Sheng M, Klumperman J, Rehmann H, Jaarsma D, Kapitein LC, van der Sluijs P (2010), Neuron specific Rab4 effector GRASP-1 coordinates membrane specialization and maturation of recycling endosomes, PLoS Biol, 8, e1000283.

see:

http://www.cellbiology-utrecht.nl/facilities/cmc/equipment.html

http://www.cellbiology-utrecht.nl/facilities/csc/equipment.html

www.cellbiology-utrecht.nl/
see:

http://www.cellbiology-utrecht.nl/facilities/cmc/services.html

http://www.cellbiology-utrecht.nl/facilities/csc/screening.html

Annual Cry0-Immuno Gold course on Cryomethods, Ultracryotomy and Immunolabeling

http://www.cellbiology-utrecht.nl/jobs_education/cryo_course.html

Yes