S. van den Heuvel,
|Live-cell imaging, Imaging of C. elegans, Laser spindle severing|
|The developmental biology division is home to several research groups that share a common interest in the development of multicellular organisms. Sander van den Heuvel studies the regulation of cell division in the context of animal development. Research topics in the group include asymmetric cell division, the control of cell-cycle entry, and the regulation of differentiation vs. proliferation. C. elegans is the main model system used for these studies, with less frequent use of mammalian tissue culture systems. Mike Boxem addresses the establishment of cell polarity through a combination of systematic protein interaction mapping and in vivo studies in C. elegans.
Rüdiger Schulz studies basic questions regarding the control of spermatogonial stem cell divisions in Zebrafish, as well as applied questions on the reproduction of commercial fish including Salmon and Cod. Inge The studies the regulation of cell proliferation vs. differentiation in collaboration with the group of Sander van den Heuvel.
|Wildwater M, Sander N, de Vreede G, van den Heuvel S. Cell shape and Wnt signaling redundantly control the division axis of C. elegans epithelial stem cells. Development. 2011 Oct;138(20):4375-85.
Galli M, Muñoz J, Portegijs V, Boxem M, Grill SW, Heck AJ, van den Heuvel S. aPKC phosphorylates NuMA-related LIN-5 to position the mitotic spindle during asymmetric division. Nat. Cell Biol. 2011 Aug 21;13(9):1132-8.
Korzelius J, The I, Ruijtenberg S, Portegijs V, Xu H, Horvitz HR, van den Heuvel S. C. elegans MCM-4 is a general DNA replication and checkpoint component with an epidermis-specific requirement for growth and viability. Dev. Biol. 2011 Feb 15;350(2):358-69.
van der Voet M, Berends CW, Perreault A, Nguyen-Ngoc T, Gönczy P, Vidal M, Boxem M, van den Heuvel S. NuMA-related LIN-5, ASPM-1, calmodulin and dynein promote meiotic spindle rotation independently of cortical LIN-5/GPR/Galpha. Nat. Cell Biol. 2009 Mar;11(3):269-77.
|Zeiss Axiovert 200, DIC microinjection system
Zeiss Axioplan 2 fluorescence microscope with ApoTome and CCD camera
Andor spinning disc microscope equiped with EM-CCD camera.